Published in
Elsevier, Molecular Brain Research, 2(77), p. 290-293
DOI: 10.1016/s0169-328x(00)00069-3
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Detection of the interleukin 18 family in rat brain by RT-PCR.
Journal article published in 2000 by
Rachel D. Wheeler,
Culhane A Hall M Pickering-Brown S Rothwell NJ Luheshi G. Wheeler R.,
Aedin C. Culhane 
,
Matthew D. Hall,
Stuart Pickering-Brown,
Nancy J. Rothwell,
Giamal N. Luheshi
,
Matthew D. Hall,
Stuart Pickering-Brown,
Nancy J. Rothwell,
Giamal N. Luheshi
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Abstract
Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL-18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR.