Published in

Elsevier, NeuroImage, (84), p. 45-64

DOI: 10.1016/j.neuroimage.2013.07.072

Links

Tools

Export citation

Search in Google Scholar

Post-hoc power estimation for topological inference in fMRI

Journal article published in 2014 by Joke Durnez ORCID, Beatrijs Moerkerke, Thomas E. Nichols
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Green circle
Postprint: archiving allowed
Green circle
Published version: archiving allowed
Data provided by SHERPA/RoMEO

Abstract

When analyzing functional MRI data, several thresholding procedures are available to account for the huge number of volume units or features that are tested simultaneously. The main focus of these methods is to prevent an inflation of false positives. However, this comes with a serious decrease in power and leads to a problematic imbalance between type I and type II errors. In this paper, we show how estimating the number of activated peaks or clusters enables one to estimate post-hoc how powerful the selection procedure performs. This procedure can be used in real studies as a diagnostics tool, and raises awareness on how much activation is potentially missed. The method is evaluated and illustrated using simulations and a real data example. Our real data example illustrates the lack of power in current fMRI research.