IMPROHEALTH II is a European pilot project funded by the Leonardo Da Vinci action program, aiming to improve the quality, efficiency, and effectiveness of healthcare services through vocational education and training of healthcare professionals. One of the main goals of this project is the establishment of a web based virtual quality center (VQC), which will allow healthcare professionals and students from health educational programs to obtain through an e-learning process the required knowledge, skills, and capabilities in the field of health informatics. This paper aims to present the IMPROHEALTH II pilot project and the main modules of its web based virtual quality center (VCQ). In addition, it discusses the main materials and methods of the new health informatics course and its interactive web-based educational environment.