Elsevier, Tetrahedron Letters, 47(41), p. 9049-9051
DOI: 10.1016/s0040-4039(00)01649-x
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Resolution of racemic synthetic tetra-O-benzylcatechin 2 is described, through the formation of esters 5 and 6 derived from dibenzoyl-L-tartaric acid. The diastereoisomer of the natural series 6 was separated by crystallization, the other one being an oil. This process allowed us to prepare enantiomerically pure (+)-catechin 8 in high yield. The pure isomer in the ent-series 9 could be obtained, following the same scheme of reactions. (C) 2000 Elsevier Science Ltd. All rights reserved.