Published in
Royal Society of Chemistry, Chemical Science, 29(14), p. 7936-7943, 2023
DOI: 10.1039/d3sc01240a
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A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway
Journal article published in 2023 by
Jie Liu 
,
Ruirui Zhang ,
Shubhadip Mallick,
Sohan Patil,
Chantal Wientjens,
Jana Flegel,
Anna Krupp,
Carsten Strohmann,
Corentin Grassin ,
Christian Merten ,
Axel Pahl,
Michael Grigalunas ,
Herbert Waldmann
,
Ruirui Zhang ,
Shubhadip Mallick,
Sohan Patil,
Chantal Wientjens,
Jana Flegel,
Anna Krupp,
Carsten Strohmann,
Corentin Grassin ,
Christian Merten ,
Axel Pahl,
Michael Grigalunas ,
Herbert Waldmann
This paper is made freely available by the publisher.
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Abstract
Synthesis of pyrrolo[3,2-c]quinoline pseudo-natural products by means of a highly enantioselective intramolecular 1,3-dipolar cycloaddition yielded a novel Hedgehog signalling inhibitor chemotype that targets the Smoothened protein.