Published in
American Society for Microbiology, Microbiology Spectrum, 3(10), 2022
DOI: 10.1128/spectrum.02437-21
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Three-Stage Pooled Plasma Hepatitis C Virus RNA Testing for the Identification of Acute HCV Infections in At-Risk Populations
Journal article published in 2022 by
Hsin-Yun Sun,
Chieh Chiang,
Sung-Hsi Huang,
Wen-Jin Guo,
Yu-Chung Chuang 
,
Yi-Chia Huang,
Chia-Jui Yang,
Li-Hsin Su,
Yi-Ting Chen,
Yea-Wen Chen,
Fu-Chiang Hsu,
Shu-Yuan Ho,
Wen-Chun Liu,
Yi-Ching Su,
Sui-Yuan Chang
and other authors.
,
Yi-Chia Huang,
Chia-Jui Yang,
Li-Hsin Su,
Yi-Ting Chen,
Yea-Wen Chen,
Fu-Chiang Hsu,
Shu-Yuan Ho,
Wen-Chun Liu,
Yi-Ching Su,
Sui-Yuan Chang
and other authors.
This paper is made freely available by the publisher.
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Abstract
Our three-stage pooled plasma HCV RNA testing successfully identified HCV viremia in high-risk PLWH with a testing cost reduction of 84.5%. Simulation analysis offered detailed information regarding the selection of pool and mini-pool sizes in settings of different HCV epidemiology and the performance of HCV RNA testing to optimize the cost reduction.