The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia
Journal article published in 2022 by
Chuangqi Wang 
,
Yijia Li,
Paulina Kaplonek,
Matteo Gentili,
Stephanie Fischinger,
Kathryn A. Bowman ,
Moshe Sade-Feldman,
Kyle R. Kays,
James Regan,
James P. Flynn,
Marcia B. Goldberg,
Nir Hacohen ,
Michael R. Filbin ,
Douglas A. Lauffenburger ,
Galit Alter
and other authors.
,
Yijia Li,
Paulina Kaplonek,
Matteo Gentili,
Stephanie Fischinger,
Kathryn A. Bowman ,
Moshe Sade-Feldman,
Kyle R. Kays,
James Regan,
James P. Flynn,
Marcia B. Goldberg,
Nir Hacohen ,
Michael R. Filbin ,
Douglas A. Lauffenburger ,
Galit Alter
and other authors.
This paper is made freely available by the publisher.
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Abstract
We showed that persistent SARS-CoV-2 RNAemia is an independent predictor of severe COVID-19. We observed that SARS-CoV-2-targeted antibody maturation, specifically Fc-effector functions rather than neutralization, was strongly linked with the ability to rapidly clear viremia.