Abstract The design and construction of active centres are key to exploring advanced electrocatalysts for oxygen evolution reaction (OER). In this work, we demonstrate the in situ construction of point defects on CrOOH by Ni doping (Ni-CrOOH/NF). Compared with pure CrOOH/NF, Ni-CrOOH/NF showed enhanced OER activity. The effect of the amount of Ni introduced on the OER performance was investigated. Ni_0.2-CrOOH/NF, the best introduction of Ni, uses a low overpotential of 253 mV to achieve a current density of 10 mA cm^–2 with a high turnover frequency of 0.27 s^–1 in 1.0 M NaOH. In addition, the electrocatalytic performance of Ni_0.2-CrOOH/NF showed little deterioration after 1000-cycle cyclic voltammetry scanning. In the potentiostatic test, activity was stable for at least 20 h.