Published in
American Society for Microbiology, Microbiology Spectrum, 5(10), 2022
DOI: 10.1128/spectrum.02141-22
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Pf SRPK1 Regulates Asexual Blood Stage Schizogony and Is Essential for Male Gamete Formation
Journal article published in 2022 by
Sudhir Kumar 
,
Vinay K. Baranwal ,
Amanda S. Leeb ,
Meseret T. Haile,
Kenza M. Z. Oualim,
Nina Hertoghs ,
Ashley M. Vaughan ,
Stefan H. I. Kappe
,
Vinay K. Baranwal ,
Amanda S. Leeb ,
Meseret T. Haile,
Kenza M. Z. Oualim,
Nina Hertoghs ,
Ashley M. Vaughan ,
Stefan H. I. Kappe
This paper is made freely available by the publisher.
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Abstract
Plasmodium sexual stages represent a critical bottleneck in the parasite life cycle. Gametocytes taken up in an infectious blood meal by female anopheline mosquito get activated to form gametes and fuse to form short-lived zygotes, which transform into ookinetes to infect mosquitoes.