Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 10(66), 2022
DOI: 10.1128/aac.02091-21
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RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria
Journal article published in 2022 by
Abeer Al-Zubaidi,
Chen-Yi Cheung,
Gregory M. Cook 
,
George Taiaroa ,
Valerie Mizrahi,
J. Shaun Lott ,
Stephanie S. Dawes
,
George Taiaroa ,
Valerie Mizrahi,
J. Shaun Lott ,
Stephanie S. Dawes
This paper is made freely available by the publisher.
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Abstract
Multidrug-resistant (MDR) tuberculosis (TB) is defined by the resistance of Mycobacterium tuberculosis , the causative organism, to the first-line antibiotics rifampicin and isoniazid. Mitigating or reversing resistance to these drugs offers a means of preserving and extending their use in TB treatment.