Published in
American Society for Microbiology, Microbiology Spectrum, 1(11), 2023
DOI: 10.1128/spectrum.03049-22
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Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes
Journal article published in 2023 by
Lucas Michel-Todó 
,
Cristina Bancells,
Núria Casas-Vila,
Núria Rovira-Graells,
Carles Hernández-Ferrer ,
Juan R. González,
Alfred Cortés
,
Cristina Bancells,
Núria Casas-Vila,
Núria Rovira-Graells,
Carles Hernández-Ferrer ,
Juan R. González,
Alfred Cortés
This paper is made freely available by the publisher.
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Abstract
The survival of malaria parasites in the changing human blood environment largely depends on their ability to alter gene expression by epigenetic mechanisms. The active state of Plasmodium falciparum clonally variant genes (CVGs) is associated with euchromatin characterized by the histone mark H3K9ac, whereas the silenced state is characterized by H3K9me3-based heterochromatin.