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Royal Society of Chemistry, RSC Advances, 12(13), p. 7897-7912, 2023

DOI: 10.1039/d3ra00972f

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Pyrazole-based lamellarin O analogues: synthesis, biological evaluation and structure–activity relationships

Journal article published in 2023 by Karolina Dzedulionytė ORCID, Nina Fuxreiter, Ekaterina Schreiber-Brynzak, Asta Žukauskaitė ORCID, Algirdas Šačkus, Verena Pichler ORCID, Eglė Arbačiauskienė ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Isosteric pyrrole–pyrazole exchange in the natural alkaloid lamellarin O resulted in 18 fully characterized derivatives. Obtained compounds were investigated as potent agents against human colon cancer cell lines HCT116, HT29 and SW480.