American Physiological Society, American Journal of Physiology: Cell Physiology, 1(325), p. C186-C207, 2023
DOI: 10.1152/ajpcell.00298.2022
Full text: Unavailable
The central question investigated in this study is why vascular endothelium remains inflamed and what underlying signaling is responsible. The new results show that the resolution of endothelial-controlled inflammation may be impaired or delayed because Janus kinase (JAK)/STAT activation is maintained autonomous of interferon (IFN)γ presence, and the late phase negative regulator suppressors of cytokine signaling (SOCS)1 fails to be induced.