AbstractPurposeLung cancer remains underrepresented in cancer survivorship research. This study aimed to understand survivors’ physical/psychological challenges, experiences of immunotherapy (IO) and targeted therapy (TT), and psychological adjustment through application of the Roberts et al. (2017) advanced cancer adaptation of Folkman and Greer’s appraisal and coping model.MethodsAdults 6–24 months post-initial treatment completion were recruited via an Australian cohort study. Participant demographic, clinical, quality of life, and distress data were obtained through the cohort database. Qualitative interviews were conducted and analyzed using Framework methods. Roberts et al. (2017)’s model informed data interpretation and presentation.ResultsTwenty interviews were conducted (10 females; average age 69 years). Participants’ diagnostic stages varied (stage I = 2, stage II = 4, stage III = 8, stage IV = 6); most had received IO/TT (n = 14) and were on average 17 months (range 10–24) post-diagnosis. Three themes were identified and mapped to the Roberts’ framework: (1)Ongoing illness events:most participants reported functioning well despite ongoing physical effects. Those on IO/TT reported side effects; some were unexpected/serious. (2)Adjusting to life with lung cancer:most expressed hope for the future while simultaneously preparing for disease progression. Those receiving IO/TT experienced uncertainty given limited survival information. (3)Learning to live with lung cancer:participants described emotion, problem, and meaning based on coping strategies.ConclusionsFindings may guide development of supportive care resources/interventions focused on uncertainty, IO/TT communication and decision-making, and coping.Implications for Cancer SurvivorsMany people with lung cancer are living well with their ongoing illness. Despite challenges, many survivors are adapting to issues as they arise and are maintaining a sense of hope and optimism.