Fluoride (F−) pollution in potable groundwater (GW) is a serious environmental concern in Pakistan with substantial human health hazard reports. The research on F− pollution in GW resources in Sindh Province is still incomplete. To explore the realistic conditions, the present research aimed to investigate the GW quality of community tube wells concerning F− contamination in Tharparkar, Sindh, Pakistan. A total of 53 samples were collected and examined for F−, along with other physicochemical parameters. The F− values observed varied from 0.2–4.2 mg/L, with a mean value of 1.63 mg/L. Among the 53 samples, 46% had F− levels that were higher than the World Health Organization’s (WHO) recommended limit (1.5 mg/L). The water type of the studied region was Ca-HCO3 type, which can be attributed to fresh recharged water. The interaction of rock–water contact controls the hydrochemistry of GW. The GW resources of the research zone were highly saturated with fluorite minerals. Human health risk calculation outcomes exposed that 21 samples showed high HQ values for children and 7 samples showed high values for adults in the research zone. Children are at high risk in the study area from drinking F−-contaminated GW. WQI results showed that 31 samples were not suitable for drinking.