Human B Cell Responses to Dominant and Subdominant Antigens Induced by a Meningococcal Outer Membrane Vesicle Vaccine in a Phase I Trial
Journal article published in 2022 by
Christine S. Rollier 
,
Christina Dold ,
Leanne Marsay,
Aline Linder,
Christopher A. Green,
Manish Sadarangani ,
Gunnstein Norheim,
Jeremy P. Derrick,
Ian M. Feavers,
Martin C. J. Maiden ,
Andrew J. Pollard
,
Christina Dold ,
Leanne Marsay,
Aline Linder,
Christopher A. Green,
Manish Sadarangani ,
Gunnstein Norheim,
Jeremy P. Derrick,
Ian M. Feavers,
Martin C. J. Maiden ,
Andrew J. Pollard
This paper is made freely available by the publisher.
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Abstract
Neisseria meningitidis outer membrane vesicles (OMV) are a component of the capsular group B meningococcal vaccine 4CMenB (Bexsero) and have been shown to induce 30% efficacy against gonococcal infection. They are composed of multiple antigens and are considered an interesting delivery platform for vaccines against several bacterial diseases.