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F1000Research, Wellcome Open Research, (6), p. 109, 2021

DOI: 10.12688/wellcomeopenres.16734.2

F1000Research, Wellcome Open Research, (6), p. 109, 2022

DOI: 10.12688/wellcomeopenres.16734.3

F1000Research, Wellcome Open Research, (6), p. 109, 2022

DOI: 10.12688/wellcomeopenres.16734.4

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Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.