F1000Research, Wellcome Open Research, (6), p. 109, 2021
DOI: 10.12688/wellcomeopenres.16734.2
F1000Research, Wellcome Open Research, (6), p. 109, 2022
DOI: 10.12688/wellcomeopenres.16734.3
F1000Research, Wellcome Open Research, (6), p. 109, 2022
DOI: 10.12688/wellcomeopenres.16734.4
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Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.