A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies
Journal article published in 2023 by
Frederic Bibollet-Ruche,
Ronnie M. Russell,
Wenge Ding,
Weimin Liu,
Yingying Li,
Kshitij Wagh,
Daniel Wrapp 
,
Rumi Habib,
Ashwin N. Skelly ,
Ryan S. Roark,
Scott Sherrill-Mix,
Shuyi Wang,
Juliette Rando,
Emily Lindemuth,
Kendra Cruickshank
and other authors.
,
Rumi Habib,
Ashwin N. Skelly ,
Ryan S. Roark,
Scott Sherrill-Mix,
Shuyi Wang,
Juliette Rando,
Emily Lindemuth,
Kendra Cruickshank
and other authors.
This paper is made freely available by the publisher.
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Abstract
An effective HIV-1 vaccination strategy will need to stimulate rare precursor B cells of multiple bNAb lineages and affinity mature them along desired pathways. Here, we searched for V2-apex germ line-targeting Envs among a large set of diverse primate lentiviruses and identified minimally modified versions of one chimpanzee SIV Env that bound several human V2-apex bNAb precursors and stimulated one of these in a V2-apex bNAb precursor-expressing knock-in mouse.