In this work, the results of a sensitivity study based on ICON-LAM simulations at 2.5 km of spatial resolution over the Italian area, driven by ECMWF IFS global data, are presented. The main aim is to provide a contribution to the selection of suitable parameterization schemes that result in more effective for a proper representation of the Italian climate features. Model evaluation was conducted in terms of the air temperature and precipitation for three subregions, comparing a set of 13 simulations against SCIA and E-OBS standard datasets. In addition, evaluation was also conducted against selected data stations scattered over the Italian area. We found that the ICON-LAM model was able to provide a good representation of the temperature over Italy, whereas non-negligible biases were observed for precipitation in certain regions. The model proved to be sensitive to changes in physical parameterization schemes. In particular, we found that the explicit treatment of deep convection and the “clouds as in turbulence” scheme for cloud cover allowed for a better representation of precipitation in the summer over the Alpine region. The single moment scheme is currently the best option for cloud microphysics.