ABSTRACT Future detection of high-redshift gamma-ray bursts (GRBs) will be an important tool for studying the early Universe. Fast and accurate redshift estimation for detected GRBs is key for encouraging rapid follow-up observations by ground- and space-based telescopes. Low-redshift dusty interlopers pose the biggest challenge for GRB redshift estimation using broad photometric bands, as their high extinction can mimic a high-redshift GRB. To assess false alarms of high-redshift GRB photometric measurements, we simulate and fit a variety of GRBs using phozzy, a simulation code developed to estimate GRB photometric redshifts, and test the ability to distinguish between high- and low-redshift GRBs when using simultaneously observed photometric bands. We run the code with the wavelength bands and instrument parameters for the Photo-z Infrared Telescope (PIRT), an instrument designed for the Gamow mission concept. We explore various distributions of host galaxy extinction as a function of redshift, and their effect on the completeness and purity of a high-redshift GRB search with the PIRT. We find that for assumptions based on current observations, the completeness and purity range from ∼82 to 88 per cent and from ∼84 to $\gt 99~{{\ \rm per\ cent}}$, respectively. For the priors optimized to reduce false positives, only $∼ 0.6~{{\ \rm per\ cent}}$ of low-redshift GRBs will be mistaken as a high-redshift one, corresponding to ∼1 false alarm per 500 detected GRBs.