Published in
American Society for Microbiology, Microbiology Spectrum, 2(11), 2023
DOI: 10.1128/spectrum.04213-22
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High-Throughput Mutagenesis Reveals a Role for Antimicrobial Resistance- and Virulence-Associated Mobile Genetic Elements in Staphylococcus aureus Host Adaptation
Journal article published in 2023 by
Xiaoliang Ba 
,
Marta Matuszewska,
Lajos Kalmar,
Jingyan Fan,
Geng Zou,
Desirée Corander,
Claire L. Raisen,
Shaowen Li,
Lu Li,
Lucy A. Weinert,
Alexander W. Tucker,
Andrew J. Grant ,
Rui Zhou ,
Mark A. Holmes
,
Marta Matuszewska,
Lajos Kalmar,
Jingyan Fan,
Geng Zou,
Desirée Corander,
Claire L. Raisen,
Shaowen Li,
Lu Li,
Lucy A. Weinert,
Alexander W. Tucker,
Andrew J. Grant ,
Rui Zhou ,
Mark A. Holmes
This paper is made freely available by the publisher.
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Abstract
CC398 is the dominant type of methicillin-resistant Staphylococcus aureus (MRSA) in European livestock and a growing cause of human infections. Previous studies have suggested MRSA CC398 evolved from human-associated methicillin-sensitive Staphylococcus aureus and is capable of rapidly readapting to human hosts while maintaining antibiotic resistance.