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American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 6(322), p. H1032-H1043, 2022

DOI: 10.1152/ajpheart.00664.2021

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α-Tubulin acetylation on lysine 40 controls cardiac glucose uptake

Journal article published in 2022 by Edith Renguet, Marine De Loof, Natacha Fourny, Audrey Ginion, Caroline Bouzin ORCID, Christian Poüs, Sandrine Horman, Christophe Beauloye, Laurent Bultot ORCID, Luc Bertrand ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Acetylation level of α-tubulin on K40 is increased in the heart of a diet-induced mouse model of type 2 diabetes. Pharmacological stimulation of α-tubulin K40 acetylation lowers insulin-mediated GLUT4 vesicles translocation to the plasma membrane, reducing glucose transport. Expressing a nonacetylable dominant form of α-tubulin boosts glucose uptake in both insulin-sensitive and insulin-resistant cardiomyocytes.