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American Association for the Advancement of Science, Science Advances, 35(7), 2021

DOI: 10.1126/sciadv.abj4282

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Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

Journal article published in 2021 by Manoj K. Rathinaswamy ORCID, Udit Dalwadi, Kaelin D. Fleming ORCID, Carson Adams, Jordan T. B. Stariha ORCID, Els Pardon ORCID, Minkyung Baek ORCID, Oscar Vadas ORCID, Frank DiMaio ORCID, Jan Steyaert ORCID, Scott D. Hansen ORCID, Calvin K. Yip ORCID, John E. Burke ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The structure of class IB PI3K (p110γ-p101) reveals mechanism of GPCR activation and differences from class IA PI3Ks.