Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro , despite Eliciting a Prolonged Antiviral Response
Journal article published in 2022 by
Akshamal M. Gamage,
De Yun Wang,
Kai Sen Tan,
Lin-Fa Wang 
,
Wharton O. Y. Chan,
Zhe Zhang Ryan Lew,
Jing Liu,
Chee Wah Tan ,
Deepa Rajagopalan,
Quy Xiao Xuan Lin,
Le Min Tan,
Yew Kwang Ong,
Mark Thong,
Raymond Tzer Pin Lin,
Prasanna Nori Venkatesh
and other authors.
,
Wharton O. Y. Chan,
Zhe Zhang Ryan Lew,
Jing Liu,
Chee Wah Tan ,
Deepa Rajagopalan,
Quy Xiao Xuan Lin,
Le Min Tan,
Yew Kwang Ong,
Mark Thong,
Raymond Tzer Pin Lin,
Prasanna Nori Venkatesh
and other authors.
This paper is made freely available by the publisher.
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Abstract
Increasing medical attention has been drawn to the persistence of symptoms (long-COVID syndrome) or live virus shedding from subsets of COVID-19 patients weeks to months after the initial onset of symptoms. In vitro approaches to model viral or symptom persistence are needed to fully dissect the complex and likely varied mechanisms underlying these clinical observations. We show that in vitro differentiated human NECs are persistently infected with SARS-CoV-2 for up to 28 dpi.