AbstractDetermining international climate mitigation response strategies is a complex task. Integrated Assessment Models support this process by analysing the interplay of the most relevant factors, including socio-economic developments, climate system uncertainty, damage estimates, mitigation costs and discount rates. Here, we develop a meta-model that disentangles the uncertainties of these factors using full literature ranges. This model allows comparing insights of the cost-minimising and cost-benefit modelling communities. Typically, mitigation scenarios focus on minimum-cost pathways achieving the Paris Agreement without accounting for damages; our analysis shows doing so could double the initial carbon price. In a full cost-benefit setting, we show that the optimal temperature target does not exceed 2.5 °C when considering medium damages and low discount rates, even with high mitigation costs. With low mitigation costs, optimal temperature change drops to 1.5 °C or less. The most important factor determining the optimal temperature is the damage function, accounting for 50% of the uncertainty.