Published in
American Association for the Advancement of Science, Science Translational Medicine, 591(13), 2021
DOI: 10.1126/scitranslmed.abb0411
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Sustained fetal hemoglobin induction in vivo is achieved by BCL11A interference and coexpressed truncated erythropoietin receptor
Journal article published in 2021 by
Naoya Uchida 
,
Francesca Ferrara ,
Claire M. Drysdale ,
Morgan Yapundich ,
Jackson Gamer ,
Tina Nassehi ,
Julia DiNicola ,
Yoshitaka Shibata ,
Matthew Wielgosz ,
Yoon-Sang Kim ,
Matthew Bauler ,
Robert E. Throm ,
Juan J. Haro-Mora ,
Selami Demirci,
Aylin C. Bonifacino
and other authors.
,
Francesca Ferrara ,
Claire M. Drysdale ,
Morgan Yapundich ,
Jackson Gamer ,
Tina Nassehi ,
Julia DiNicola ,
Yoshitaka Shibata ,
Matthew Wielgosz ,
Yoon-Sang Kim ,
Matthew Bauler ,
Robert E. Throm ,
Juan J. Haro-Mora ,
Selami Demirci,
Aylin C. Bonifacino
and other authors.
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Abstract
In xenograft mice and nonhuman primates, BCL11A interference and coexpression of a truncated erythropoietin receptor led to sustained hemoglobin F.