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Royal Society of Chemistry, Chemical Science, 10(12), p. 3768-3785, 2021

DOI: 10.1039/d0sc04769d

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Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPC binding and downstream pathways

Journal article published in 2021 by James D. Grayson, Matthew P. Baumgartner, Cleide Dos Santos Souza, Samuel J. Dawes, Imane Ghafir El Idrissi, Jennifer C. Louth, Sasha Stimpson, Emma Mead, Charlotte Dunbar, Joanna Wolak, Gary Sharman, David Evans ORCID, Anastasia Zhuravleva ORCID, Margarita Segovia Roldan, Nicola Antonio Colabufo ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A new approach combining virtual screening,19F and STD NMR, and biochemical assays using hiPSC and targetting multiple pathways involving Aβ, PrPCand Tau provides a more effective strategy for Alzheimer's disease drug discovery than Aβ only approach.