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Royal Society of Chemistry, Chemical Science, 5(12), p. 1869-1885, 2021

DOI: 10.1039/d0sc05971d

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The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms

Journal article published in 2021 by Mahmudul Hasan ORCID, Hamed Khakzad ORCID, Lotta Happonen ORCID, Anders Sundin ORCID, Johan Unge ORCID, Uwe Mueller ORCID, Johan Malmström ORCID, Gunilla Westergren-Thorsson ORCID, Lars Malmström ORCID, Ulf Ellervik ORCID, Anders Malmström ORCID, Emil Tykesson ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Structural studies of human DS-epi1 suggests a new catalytic isomerization mechanism and reveals remarkable similarities to bacterial proteins.