Preliminary results on an electrosynthesized ion imprinted polymeric film (IIP-film) for Cd(II) ions determination in sensor development are here reported. The sensor was prepared by electropolymerization of 4-aminophenylacetic acid (4-APA) monomer in presence of Cd(II) ions, which acts as the template. The screen-printed carbon electrodes (SPCE) were used as transducer during sensor development, whereas the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were selected as the electrochemical methods for the synthesis and Cd(II) ions sensing, respectively. The incubation of the developed sensor in NaOH 250 mM involved into remove the template and the formation of specific recognition cavities into the polymer. A multivariate optimization based on central composite design (CCD) was employed to study the effect of three independent parameters on electrochemical performances of the sensor. The electrochemical characterization of sensors was performed in ferrocyanide-ferricyanide redox couple and in KCl 0.1 M, the latter revealing redox properties from the polymeric film. The performances of sensors and the control (non-imprinted film, NIP) was observed in sodium acetate buffer (100 mM, pH = 5) over the Cd(II) concentration range 0.1–10 µM.