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Royal Society of Chemistry, RSC Chemical Biology, 5(1), p. 379-384, 2020

DOI: 10.1039/d0cb00146e

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Chemical synthesis of a haemathrin sulfoprotein library reveals enhanced thrombin inhibition following tyrosine sulfation

Journal article published in 2020 by Daniel Clayton, Jessica Sayers, Jorge Ripoll-Rozada ORCID, Pedro José Barbosa Pereira ORCID, Richard J. Payne ORCID, Luke J. Dowman, Sameer S. Kulkarni ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The synthesis and thrombin inhibitory activity of eight homogeneously sulfated variants of the haemathrin proteins from tick saliva is described.