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IUPHAR/BPS Guide to Pharmacology CITE, 4(2020), 2020

DOI: 10.2218/gtopdb/f30/2020.4

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Glycoprotein hormone receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Journal article published in 2020 by Sabine Costagliola, James A. Dias, Marvin Gershengorn, Adam J. Pawson ORCID, Deborah L. Segaloff, Axel P. N. Themmen, Gilbert Vassart
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Glycoprotein hormone receptors (provisional nomenclature [45]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [120].