Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production
Journal article published in 2020 by
Ricardo S. Cardoso 
,
Lucas Alves Tavares ,
Bruna Lais S. Jesus,
Miria F. Criado ,
Andreia Nogueira de Carvalho,
Juliano de Paula Souza,
Juliano de Paula Souza,
Sukhmani Bedi,
Marcos Michel de Souza,
Maria Lucia Silva,
Guilherme Pauperio Lanfredi,
Brenda Cristina Vitti,
Orlando Bonito Scudero,
Vitor Marcel Faça,
Akira Ono
and other authors.
,
Lucas Alves Tavares ,
Bruna Lais S. Jesus,
Miria F. Criado ,
Andreia Nogueira de Carvalho,
Juliano de Paula Souza,
Juliano de Paula Souza,
Sukhmani Bedi,
Marcos Michel de Souza,
Maria Lucia Silva,
Guilherme Pauperio Lanfredi,
Brenda Cristina Vitti,
Orlando Bonito Scudero,
Vitor Marcel Faça,
Akira Ono
and other authors.
This paper is made freely available by the publisher.
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Abstract
The present study contributes new knowledge to understand HRSV assembly by providing evidence that nonglycosylated structural proteins M and N interact with elements of the secretory pathway, shedding light on their intracellular traffic. To the best of our knowledge, the present contribution is important given the scarcity of studies about the traffic of HRSV nonglycosylated proteins, especially by pointing to the involvement of SNX2, a retromer component, in the HRSV assembly process.