American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(64), 2020
DOI: 10.1128/aac.01610-20
Full text: Unavailable
Multidrug therapy is often required. Examples include antiviral therapy, nosocomial infections, and, most commonly, anti- Mycobacterium tuberculosis therapy. Our laboratory previously identified a mathematical approach to identify 2-drug regimens with a synergistic or additive interaction using a full factorial study design. Our objective here was to generate a method to identify an optimal 3-drug therapy. We studied M. tuberculosis isolate H37Rv in log-phase growth in flasks.