American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 3(319), p. H519-H530, 2020
DOI: 10.1152/ajpheart.00275.2020
Full text: Unavailable
This work identifies the contribution of electrical and mechanical alterations to regulation of calcium and force under exercise-like conditions using a novel human electromechanical model integrating ventricular electrophysiology and sarcomere mechanics. By better understanding their individual and combined effects, this can uncover arrhythmogenic mechanisms in exercise-like situations. This publicly available model is a crucial step toward understanding the complex interplay between cardiac electrophysiology and mechanics to improve arrhythmia risk prediction and treatment.