National Academy of Sciences, Proceedings of the National Academy of Sciences, 30(117), p. 17977-17983, 2020
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Significance Hepatitis delta virus (HDV) aggravates hepatitis B virus (HBV) infection of liver cells. Although the viruses are evolutionarily unrelated, HDV depends on HBV because it requires the HBV envelope protein for its transmission. HDV is only described in humans, which has triggered diverse hypotheses regarding its evolution and origins. Here we show that spiny rats ( Proechimys semispinosus ) carry a counterpart to HDV that surprisingly does not cause hepatitis and is not linked to HBV. The rodent deltavirus finding alone, but also taken together with the recent deltavirus findings in snakes and other vertebrates and invertebrates, suggests that a deltavirus precursor may have infected mammals before it acquired dependence on HBV as seen in humans.