Ten rings on one axle Rotaxanes consist of molecular rings threaded on a central axle. Most approaches to their synthesis have focused on introducing a single ring per axle. Qiu et al. now report a systematic approach to threading up to 10 adjacent rings consecutively. The axle's end groups were constructed to attract free-floating rings when reduced and then to push those rings toward the center upon oxidation. Products of each successive reduction-oxidation cycle were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. Science , this issue p. 1247