Abstract The MyShake project aims to build a global smartphone seismic network to facilitate large-scale earthquake early warning (EEW) and other applications by leveraging the power of crowdsourcing. The MyShake mobile application first detects earthquake shaking on a single phone. The earthquake is then confirmed on the MyShake servers using a “network detection” algorithm that is activated by multiple single-phone detections. In part two of this two-article series, we report the first-order performance of MyShake’s EEW capability in various selected locations around the world. Because of the present sparseness of the MyShake network in most parts of the world, we use our simulation platform to understand and evaluate the system’s performance in various tectonic settings. We assume that 0.1% of the population in each region has the MyShake mobile application installed on their smartphone and use historical earthquakes from the last 20 yr to simulate triggering scenarios with different network configurations in various regions. Then, we run the detection algorithm with these simulated triggers to understand the performance of the system. The system performs best in regions featuring high population densities and onshore, upper crustal earthquakes M<7.0. In these cases, alerts can be generated ∼4–6 s after the origin time, magnitude errors are within ∼0.5 magnitude units, and epicenters are typically within 10 km of true locations. When the events are offshore or in sparsely populated regions, the alerts are slower and the uncertainties in magnitude and location increase. Furthermore, even with 0.01% of the population as the MyShake users, in regions of high population density, the system still performs well for earthquakes larger than M 5.5. The details of the simulation platform and the network detection algorithm are available in part 1 of this two-article series.