Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 28(18), p. 5359-5369, 2020
DOI: 10.1039/d0ob00831a
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Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction
Journal article published in 2020 by
Alexander V. Strizhak,
Oleg Babii 
,
Sergii Afonin ,
Iuliia Bakanovich,
Teodors Pantelejevs,
Wenshu Xu,
Elaine Fowler ,
Rohan Eapen ,
Krishna Sharma ,
Maxim O. Platonov ,
Vasyl V. Hurmach,
Laura Itzhaki,
Marko Hyvönen ,
Anne S. Ulrich ,
David R. Spring
and other authors.
,
Sergii Afonin ,
Iuliia Bakanovich,
Teodors Pantelejevs,
Wenshu Xu,
Elaine Fowler ,
Rohan Eapen ,
Krishna Sharma ,
Maxim O. Platonov ,
Vasyl V. Hurmach,
Laura Itzhaki,
Marko Hyvönen ,
Anne S. Ulrich ,
David R. Spring
and other authors.
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Abstract
Photoisomerization of diarylethene-modified peptides changes the thermodynamics of their binding to MDM2: the “closed” photoisomers bind largely due to a high negative enthalpy, whereas the “open” forms bind better due to a more favourable entropy.