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American Association for the Advancement of Science, Science Signaling, 625(13), 2020

DOI: 10.1126/scisignal.aaz3140

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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Journal article published in 2020 by Alexander Gillis ORCID, Arisbel B. Gondin ORCID, Andrea Kliewer ORCID, Julie Sanchez ORCID, Herman D. Lim, Claudia Alamein ORCID, Preeti Manandhar ORCID, Marina Santiago ORCID, Sebastian Fritzwanker, Frank Schmiedel, Frank Schmidel, Timothy A. Katte ORCID, Tristan Reekie ORCID, Natasha L. Grimsey ORCID, Michael Kassiou ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Low intrinsic efficacy can explain the reduced side effects of apparently biased μ-opioid receptor agonists.