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Oxford University Press (OUP), Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders, 1(35), p. 213-221

DOI: 10.1093/schbul/sbm153

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Impaired Flush Response to Niacin Skin Patch Among Schizophrenia Patients and Their Nonpsychotic Relatives: The Effect of Genetic Loading

Journal article published in 2008 by 張書森;劉智民;林聖翔;胡海國;黃宗正;劉絮愷;謝明憲;郭錫卿;陳為堅, Chih-Min Liu, Sheng-Hsiang Lin, Hai-Gwo Hwu, Tzung J. Hwang ORCID, S.-S; Liu C.-M; Lin S.-H; Hwu H.-G; Hwang T.-J; Liu Sk; Hsieh M.-H; Guo S.-C; Chen Wj; Chang, Shi K. Liu, Ming H. Hsieh, Shi-Chin Guo, Shu-Sen; Liu Chih-Min; Lin Sheng-Hsiang; Hwu Hai-Gwo; Hwang Tzung J.; Liu Shi K.; Hsieh Ming H.; Guo Shi-Chin; Chen Wei J. Chang, Wei J. Chen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives. However, little is known about whether this abnormal skin response is associated with genetic loading for schizophrenia. This study compared the niacin flush response in subjects from families with only one member affected with schizophrenia (simplex families) with those from families having a sib-pair with schizophrenia (multiplex families). Subjects were patients with schizophrenia and their nonpsychotic first-degree relatives from simplex families (176 probands, 260 parents, and 80 siblings) and multiplex families (311 probands, 180 parents, and 52 siblings) as well as 94 healthy controls. Niacin patches of 3 concentrations (0.001M, 0.01M, and 0.1M) were applied to forearm skin, and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. More attenuated flush response to topical niacin was shown in schizophrenia probands and their relatives from multiplex families than in their counterparts from simplex families, and the differentiation was better revealed using 0.1M concentration of niacin than 0.01M or 0.001M. For the highest concentration of 0.1M and the longest time lag of 15 minutes, a subgroup of probands ( 23%), parents (27%), and siblings (19%) still exhibited nonflush response. Flush response to niacin skin patch is more impaired in schizophrenia patients and their relatives from families with higher genetic loading for schizophrenia, and this finding has implications for future genetic dissection of schizophrenia. ; 醫學系精神科 ; 醫學系 ; 醫學院 ; 期刊論文