Published in
Royal Society of Chemistry, RSC Advances, 9(10), p. 5191-5195, 2020
DOI: 10.1039/d0ra00257g
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Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a]pyrimidines as potential anti-chikungunya agents
Journal article published in 2020 by
Mohamed Fares 
,
Patrick M. McCosker ,
Muhammad A. Alsherbiny ,
Anthony C. Willis,
Timothy Clark ,
Johan Neyts ,
Dirk Jochmans ,
Paul A. Keller
,
Patrick M. McCosker ,
Muhammad A. Alsherbiny ,
Anthony C. Willis,
Timothy Clark ,
Johan Neyts ,
Dirk Jochmans ,
Paul A. Keller
This paper is made freely available by the publisher.
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Abstract
Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidines was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde.