Abstract The outdoor radon concentration was monitored together with the meteorological parameters at two contrasting complex topographies: sub-Alpine basin (SA) and sub-Mediterranean valley (SM) in winter (December 2017–February 2018) and summer (June–August 2018). The time series for each site and each season are evaluated in three different ways: (i) clear-sky and cloudy condition together, (ii) clear-sky conditions only (cloud cover <20%) and (iii) cloudy condition only (cloud cover >20%), and compared to the expected atmospheric boundary layer (ABL) ‘mixing volume’ caused by meteorological changes. The results have confirmed the sensitivity of diurnal and seasonal radon concentration to the expected ABL ‘mixing volume’ at the two selected sites. The relationship is more pronounced in calm clear-sky conditions. Cloudy conditions are associated with fast weather changes, when the ABL is well mixed and hourly mean radon concentrations do not follow the typical diurnal trend.