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Royal Society of Chemistry, Chemical Science, 10(11), p. 2843-2854, 2020

DOI: 10.1039/c9sc04722k

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Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab

Journal article published in 2020 by Firdaus Samsudin ORCID, Joshua Yi Yeo, Samuel Ken-En Gan ORCID, Peter J. Bond ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The IgM antibody isotype of Pertuzumab affords simultaneous binding to antigens, but similar binding in Trastuzumab is hindered by steric clashes.