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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(63), 2019

DOI: 10.1128/aac.00384-19

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Limited Sampling Strategies Using Linear Regression and the Bayesian Approach for Therapeutic Drug Monitoring of Moxifloxacin in Tuberculosis Patients

Journal article published in 2019 by Simone H. J. van den Elsen, Marieke G. G. Sturkenboom, Onno W. Akkerman ORCID, Katerina Manika, Ioannis P. Kioumis, Tjip S. van der Werf, John L. Johnson, Charles Peloquin ORCID, Daan J. Touw, Jan-Willem C. Alffenaar
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Therapeutic drug monitoring (TDM) of moxifloxacin is recommended to improve the response to tuberculosis treatment and reduce acquired drug resistance. Limited sampling strategies (LSSs) are able to reduce the burden of TDM by using a small number of appropriately timed samples to estimate the parameter of interest, the area under the concentration-time curve.