Published in
Royal Society of Chemistry, Organic Chemistry Frontiers, 4(6), p. 426-431, 2019
DOI: 10.1039/c8qo01054d
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Silver-promoted selective fluorination of 2-aminopyrimidines: synthesis of 5-fluoro-2-aminopyrimidine derivatives
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Abstract
Ag-Promoted selective fluorination of 2-aminopyrimidine derivatives with Selectfluor is presented, giving 4-substituted 5-fluoro-2-aminopyrimidines in fair to high yields with excellent regioselectivities.