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SAGE Publications, Evolutionary Bioinformatics, (15), p. 117693431882053, 2019

DOI: 10.1177/1176934318820534

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Linearization of Median Genomes Under the Double-Cut-and-Join-Indel Model

Journal article published in 2019 by Pavel Avdeyev ORCID, Shuai Jiang, Max A. Alekseyev ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Reconstruction of the median genome consisting of linear chromosomes from three given genomes is known to be intractable. There exist efficient methods for solving a relaxed version of this problem, where the median genome is allowed to have circular chromosomes. We propose a method for construction of an approximate solution to the original problem from a solution to the relaxed problem and prove a bound on its approximation error. Our method also provides insights into the combinatorial structure of genome transformations with respect to appearance of circular chromosomes.