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Dove Press, International Journal of Nanomedicine, p. 2361

DOI: 10.2147/ijn.s30467

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Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity

Journal article published in 2012 by Marco Cantisani, Stefania Galdiero ORCID, Mariateresa Vitiello, Annarita Falanga ORCID, Emiliana Finamore, Marilena Galdiero
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial infection in young children. It is characterized by inflammation that is mainly mediated by cytokines and chemokines. One of the most abundant components of the Hib outer membrane is the P2 porin, which has been shown to induce the release of several inflammatory cytokines. A synthetic peptide corresponding to loop L7 of the porin activates JNK and p38 mitogen-activated protein kinase (MAPK) pathways. We report a novel use of the complementary peptide approach to design a peptide that is able to bind selectively to the protein P2, thereby reducing its activity. This work provides insights into essential molecular details of P2 that may affect the pathogenesis of Hib infections where interruption of the signaling cascade could represent an attractive therapeutic strategy.