Published in
American Society of Hematology, Blood, 12(129), p. 1707-1717
DOI: 10.1182/blood-2016-08-734988
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Polyphosphate nanoparticles on the platelet surface trigger contact system activation
Journal article published in 2017 by
Johan J. F. Verhoef 
,
Arjan D. Barendrecht ,
Katrin F. Nickel ,
Kim Dijkxhoorn,
Ellinor Kenne ,
Linda Labberton ,
Owen J. T. McCarty ,
Raymond Schiffelers ,
Harry F. Heijnen ,
Antoni P. Hendrickx,
Huub Schellekens,
Marcel H. Fens ,
Steven de Maat ,
Thomas Renné ,
Coen Maas
,
Arjan D. Barendrecht ,
Katrin F. Nickel ,
Kim Dijkxhoorn,
Ellinor Kenne ,
Linda Labberton ,
Owen J. T. McCarty ,
Raymond Schiffelers ,
Harry F. Heijnen ,
Antoni P. Hendrickx,
Huub Schellekens,
Marcel H. Fens ,
Steven de Maat ,
Thomas Renné ,
Coen Maas
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Abstract
Key Points Activated platelets expose insoluble membrane-associated polyphosphate nanoparticles that are complexed with divalent metal ions. Platelet polyphosphate nanoparticles, but not soluble polyphosphate polymers, activate the contact system.