Published in

American Society for Microbiology, Journal of Virology, 10(86), p. 5774-5781, 2012

DOI: 10.1128/jvi.00137-12

Links

Tools

Export citation

Search in Google Scholar

Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes

Journal article published in 2012 by Rong Hai, Florian Krammer ORCID, Gene S. Tan, Natalie Pica, Dirk Eggink ORCID, Jad Maamary, Irina Margine, Randy A. Albrecht, Peter Palese
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

ABSTRACT The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding and a stalk domain at the membrane-proximal region. We generated functional influenza viruses expressing chimeric hemagglutinins encompassing a variety of globular head and stalk combinations, not only from different hemagglutinin subtypes but also from different hemagglutinin phylogenetic groups. These chimeric recombinant viruses possess growth properties similar to those of wild-type influenza viruses and can be used as reagents to measure domain-specific antibodies in virological and immunological assays.