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Public Library of Science, PLoS ONE, 7(9), p. e102711, 2014

DOI: 10.1371/journal.pone.0102711

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Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues

Journal article published in 2014 by Giulia Biffi ORCID, David Tannahill ORCID, Jodi Miller, William J. Howat, Shankar Balasubramanian
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Four-stranded G-quadruplex DNA secondary structures have recently been visualized in the nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody, can be used to stain DNA G-quadruplex structures in patient-derived tissues using immunohistochemistry. We observe a significantly elevated number of G-quadruplex-positive nuclei in human cancers of the liver and stomach as compared to background non-neoplastic tissue. Our results suggest that G-quadruplex formation can be detected and measured in patient-derived material and that elevated G-quadruplex formation may be a characteristic of some cancers.